Publications

Yousefpour P, Zhang YJ, Maiorino L, Melo MB, Arainga Ramirez MA, Kumarapperuma SC, Xiao P, Silva M, Li N, Michaels KK, Georgeson E, Eskandarzadeh S, Kubitz M, Groschel B, Qureshi K, Fontenot J, Hangartner L, Nedellec R, Love JC, Burton DR, Schief WR, Villinger FJ, Irvine DJ. Modulation of antigen delivery and lymph node activation in nonhuman primates by saponin adjuvant saponin/monophosphoryl lipid A nanoparticle. PNAS Nexus. 2024 Nov 25;3(12):pgae529. doi: 10.1093/pnasnexus/pgae529. PMID: 39677368; PMCID: PMC11645456.

Pires IS, Hostetler A, Covarrubias G, Carlo IS, Suggs JR, Kim BJ, Pickering AJ, Gordon E, Irvine DJ, Hammond PT. Charge-Stabilized Nanodiscs as a New Class of Lipid Nanoparticles. Adv Mater. 2024 Dec;36(52):e2408307. doi: 10.1002/adma.202408307. Epub 2024 Nov 14. PMID: 39543433; PMCID: PMC11681300.

Roerden M, Castro AB, Cui Y, Harake N, Kim B, Dye J, Maiorino L, White FM, Irvine DJ, Litchfield K, Spranger S. Neoantigen architectures define immunogenicity and drive immune evasion of tumors with heterogenous neoantigen expression. J Immunother Cancer. 2024 Nov 9;12(11):e010249. doi: 10.1136/jitc-2024-010249. PMID: 39521615; PMCID: PMC11552027.

Morgan DM, Zhang YJ, Kim JH, Murillo M, Singh S, Loschko J, Surendran N, Sekulovic O, Feng E, Shi S, Irvine DJ, Patil SU, Kanevsky I, Chorro L, Christopher Love J. Full-length single-cell BCR sequencing paired with RNA sequencing reveals convergent responses to pneumococcal vaccination. Commun Biol. 2024 Sep 28;7(1):1208. doi: 10.1038/s42003-024-06823-0. PMID: 39341987; PMCID: PMC11438910.

Bhagchandani SH, Yang L, Lam JH, Maiorino L, Ben-Akiva E, Rodrigues KA, Romanov A, Suh H, Aung A, Wu S, Wadhera A, Chakraborty AK, Irvine DJ. Two-dose priming immunization amplifies humoral immunity by synchronizing vaccine delivery with the germinal center response. Sci Immunol. 2024 Sep 20;9(99):eadl3755. doi: 10.1126/sciimmunol.adl3755. Epub 2024 Sep 20. PMID: 39303017; PMCID: PMC11492009.

Lensch V, Gabba A, Hincapie R, Bhagchandani SH, Basak A, Alam MM, Noble J, Irvine DJ, Shalek AK, Johnson JA, Finn MG, Kiessling LL. Carbohydrate-Lectin Interactions Reprogram Dendritic Cells to Promote Type 1 Anti-Tumor Immunity. ACS Nano. 2024 Oct 1;18(39):26770-26783. doi: 10.1021/acsnano.4c07360. Epub 2024 Sep 16. PMID: 39283240; PMCID: PMC11646345.

Sivanand S, Gultekin Y, Winter PS, Vermeulen SY, Tchourine KM, Abbott KL, Danai LV, Gourgue F, Do BT, Crowder K, Kunchok T, Lau AN, Darnell AM, Jefferson A, Morita S, Duda DG, Aguirre AJ, Wolpin BM, Henning N, Spanoudaki V, Maiorino L, Irvine DJ, Yilmaz OH, Lewis CA, Vitkup D, Shalek AK, Vander Heiden MG. Cancer tissue of origin constrains the growth and metabolism of metastases. Nat Metab. 2024 Sep;6(9):1668-1681. doi: 10.1038/s42255-024-01105-9. Epub 2024 Aug 19. PMID: 39160333; PMCID: PMC11450831.

Pires IS, Suggs JR, Carlo IS, Yun D, Hammond PT, Irvine DJ. Surfactant- Mediated Assembly of Precision-Size Liposomes. Chem Mater. 2024 Jul 25;36(15):7263-7273. doi: 10.1021/acs.chemmater.4c01127. PMID: 39156714; PMCID: PMC11325547.

Santollani L, Maiorino L, Zhang YJ, Palmeri JR, Stinson JA, Duhamel LR, Qureshi K, Suggs JR, Porth OT, Pinney W 3rd, Msari RA, Walsh AA, Wittrup KD, Irvine DJ. Local delivery of cell surface-targeted immunocytokines programs systemic antitumor immunity. Nat Immunol. 2024 Oct;25(10):1820-1829. doi: 10.1038/s41590-024-01925-7. Epub 2024 Aug 7. PMID: 39112631; PMCID: PMC11436379.

Cottrell CA, Pratap PP, Cirelli KM, Carnathan DG, Enemuo CA, Antanasijevic A, Ozorowski G, Sewall LM, Gao H, Allen JD, Nogal B, Silva M, Bhiman J, Pauthner M, Irvine DJ, Montefiori D, Crispin M, Burton DR, Silvestri G, Crotty S, Ward AB. Priming antibody responses to the fusion peptide in rhesus macaques. NPJ Vaccines. 2024 Jul 12;9(1):126. doi: 10.1038/s41541-024-00918-9. PMID: 38997302; PMCID: PMC11245479.

Lei K, Irvine DJ. A mobile home for T cells. Nat Mater. 2024 Jun;23(6):735-736. doi: 10.1038/s41563-024-01906-z. PMID: 38834731.

Kocabiyik O, Amlashi P, Vo AL, Suh H, Rodriguez-Aponte SA, Dalvie NC, Love JC, Andrabi R, Irvine DJ. Vaccine targeting to mucosal lymphoid tissues promotes humoral immunity in the gastrointestinal tract. Sci Adv. 2024 May 31;10(22):eadn7786. doi: 10.1126/sciadv.adn7786. Epub 2024 May 29. PMID: 38809992; PMCID: PMC11135404.

Edwards KR, Schmidt K, Homad LJ, Kher GM, Xu G, Rodrigues KA, Ben-Akiva E, Abbott J, Prlic M, Newell EW, De Rosa SC, Irvine DJ, Pancera M, McGuire AT. Vaccination with nanoparticles displaying gH/gL from Epstein-Barr virus elicits limited cross-protection against rhesus lymphocryptovirus. Cell Rep Med. 2024 Jun 18;5(6):101587. doi: 10.1016/j.xcrm.2024.101587. Epub 2024 May 22. PMID: 38781964; PMCID: PMC11228584.

Truex NL, Mohapatra S, Melo M, Rodriguez J, Li N, Abraham W, Sementa D, Touti F, Keskin DB, Wu CJ, Irvine DJ, Gómez-Bombarelli R, Pentelute BL. Design of Cytotoxic T Cell Epitopes by Machine Learning of Human Degrons. ACS Cent Sci. 2024 Mar 6;10(4):793-802. doi: 10.1021/acscentsci.3c01544. PMID: 38680558; PMCID: PMC11046456.

Xue Y, Zhang Y, Zhong Y, Du S, Hou X, Li W, Li H, Wang S, Wang C, Yan J, Kang DD, Deng B, McComb DW, Irvine DJ, Weiss R, Dong Y. LNP-RNA-engineered adipose stem cells for accelerated diabetic wound healing. Nat Commun. 2024 Jan 25;15(1):739. doi: 10.1038/s41467-024-45094-5. PMID: 38272900; PMCID: PMC10811230.

Aung A, Irvine DJ. Modulating Antigen Availability in Lymphoid Organs to Shape the Humoral Immune Response to Vaccines. J Immunol. 2024 Jan 15;212(2):171-178. doi: 10.4049/jimmunol.2300500. PMID: 38166252; PMCID: PMC10768795.

Pires IS, Ni K, Melo MB, Li N, Ben-Akiva E, Maiorino L, Dye J, Rodrigues KA, Yun D, Kim B, Hosn RR, Hammond PT, Irvine DJ. Controlled Lipid Self-Assembly for Scalable Manufacturing of Next-Generation Immune Stimulating Complexes. Chem Eng J. 2023 May 15;464:142664. doi: 10.1016/j.cej.2023.142664. Epub 2023 Mar 29. PMID: 38737525; PMCID: PMC11081102.

Bergaggio E, Tai WT, Aroldi A, Mecca C, Landoni E, Nüesch M, Mota I, Metovic J, Molinaro L, Ma L, Alvarado D, Ambrogio C, Voena C, Blasco RB, Li T, Klein D, Irvine DJ, Papotti M, Savoldo B, Dotti G, Chiarle R. ALK inhibitors increase ALK expression and sensitize neuroblastoma cells to ALK.CAR-T cells. Cancer Cell. 2023 Dec 11;41(12):2100-2116.e10. doi: 10.1016/j.ccell.2023.11.004. Epub 2023 Nov 30. PMID: 38039964; PMCID: PMC10793157.

Phung I, Rodrigues KA, Marina-Zárate E, Maiorino L, Pahar B, Lee WH, Melo M, Kaur A, Allers C, Fahlberg M, Grasperge BF, Dufour JP, Schiro F, Aye PP, Lopez PG, Torres JL, Ozorowski G, Eskandarzadeh S, Kubitz M, Georgeson E, Groschel B, Nedellec R, Bick M, Kaczmarek Michaels K, Gao H, Shen X, Carnathan DG, Silvestri G, Montefiori DC, Ward AB, Hangartner L, Veazey RS, Burton DR, Schief WR, Irvine DJ, Crotty S. A combined adjuvant approach primes robust germinal center responses and humoral immunity in non-human primates. Nat Commun. 2023 Nov 4;14(1):7107. doi: 10.1038/s41467-023-42923-x. PMID: 37925510; PMCID: PMC10625619.

Truex NL, Rondon A, Rössler SL, Hanna CC, Cho Y, Wang BY, Backlund CM, Lutz EA, Irvine DJ, Pentelute BL. Enhanced Vaccine Immunogenicity Enabled by Targeted Cytosolic Delivery of Tumor Antigens into Dendritic Cells. ACS Cent Sci. 2023 Sep 14;9(9):1835-1845. doi: 10.1021/acscentsci.3c00625. PMID: 37780364; PMCID: PMC10540291.

Yousefpour P, Ni K, Irvine DJ. Targeted modulation of immune cells and tissues using engineered biomaterials. Nat Rev Bioeng. 2023 Feb;1(2):107-124. doi: 10.1038/s44222-022-00016-2. Epub 2023 Jan 30. PMID: 37772035; PMCID: PMC10538251.

Kataria S, Qi J, Lin CW, Li Z, Dane EL, Iyer AM, Sacane J, Irvine DJ, Belcher AM. Noninvasive In Vivo Imaging of T-Cells during Cancer Immunotherapy Using Rare-Earth Nanoparticles. ACS Nano. 2023 Sep 26;17(18):17908-17919. doi: 10.1021/acsnano.3c03882. Epub 2023 Sep 7. PMID: 37676036.

Rodrigues KA, Cottrell CA, Steichen JM, Groschel B, Abraham W, Suh H, Agarwal Y, Ni K, Chang JYH, Yousefpour P, Melo MB, Schief WR, Irvine DJ. Optimization of an alum-anchored clinical HIV vaccine candidate. NPJ Vaccines. 2023 Aug 12;8(1):117. doi: 10.1038/s41541-023-00711-0. PMID: 37573422; PMCID: PMC10423202.

Nguyen KB, Roerden M, Copeland CJ, Backlund CM, Klop-Packel NG, Remba T, Kim B, Singh NK, Birnbaum ME, Irvine DJ, Spranger S. Decoupled neoantigen cross- presentation by dendritic cells limits anti-tumor immunity against tumors with heterogeneous neoantigen expression. Elife. 2023 Aug 7;12:e85263. doi: 10.7554/eLife.85263. PMID: 37548358; PMCID: PMC10425174.

Liu B, Carlson RJ, Pires IS, Gentili M, Feng E, Hellier Q, Schwartz MA, Blainey PC, Irvine DJ, Hacohen N. Human STING is a proton channel. Science. 2023 Aug 4;381(6657):508-514. doi: 10.1126/science.adf8974. Epub 2023 Aug 3. PMID: 37535724; PMCID: PMC11260435.

Mota I, Patrucco E, Mastini C, Mahadevan NR, Thai TC, Bergaggio E, Cheong TC, Leonardi G, Karaca-Atabay E, Campisi M, Poggio T, Menotti M, Ambrogio C, Longo DL, Klaeger S, Keshishian H, Sztupinszki ZM, Szallasi Z, Keskin DB, Duke- Cohan JS, Reinhold B, Carr SA, Wu CJ, Moynihan KD, Irvine DJ, Barbie DA, Reinherz EL, Voena C, Awad MM, Blasco RB, Chiarle R. ALK peptide vaccination restores the immunogenicity of ALK-rearranged non-small cell lung cancer. Nat Cancer. 2023 Jul;4(7):1016-1035. doi: 10.1038/s43018-023-00591-2. Epub 2023 Jul 10. PMID: 37430060.

Ma L, Hostetler A, Morgan DM, Maiorino L, Sulkaj I, Whittaker CA, Neeser A, Pires IS, Yousefpour P, Gregory J, Qureshi K, Dye J, Abraham W, Suh H, Li N, Love JC, Irvine DJ. Vaccine-boosted CAR T crosstalk with host immunity to reject tumors with antigen heterogeneity. Cell. 2023 Jul 20;186(15):3148-3165.e20. doi: 10.1016/j.cell.2023.06.002. Epub 2023 Jul 5. PMID: 37413990; PMCID: PMC10372881.

Zhang AQ, Hostetler A, Chen LE, Mukkamala V, Abraham W, Padilla LT, Wolff AN, Maiorino L, Backlund CM, Aung A, Melo M, Li N, Wu S, Irvine DJ. Universal redirection of CAR T cells against solid tumours via membrane-inserted ligands for the CAR. Nat Biomed Eng. 2023 Sep;7(9):1113-1128. doi: 10.1038/s41551-023-01048-8. Epub 2023 Jun 8. PMID: 37291434; PMCID: PMC10504084.

Bhagchandani SH, Vohidov F, Milling LE, Tong EY, Brown CM, Ramseier ML, Liu B, Fessenden TB, Nguyen HV, Kiel GR, Won L, Langer RS, Spranger S, Shalek AK, Irvine DJ, Johnson JA. Engineering kinetics of TLR7/8 agonist release from bottlebrush prodrugs enables tumor-focused immune stimulation. Sci Adv. 2023 Apr 21;9(16):eadg2239. doi: 10.1126/sciadv.adg2239. Epub 2023 Apr 19. PMID: 37075115; PMCID: PMC10115420.

Cable J, Graham BS, Koup RA, Seder RA, Karikó K, Pardi N, Barouch DH, Sharma B, Rauch S, Nachbagauer R, Forsell MNE, Schotsaert M, Ellebedy AH, Loré K, Irvine DJ, Pilkington E, Tahtinen S, Thompson EA, Feraoun Y, King NP, Saunders K, Alter G, Moin SM, Sliepen K, Karlsson Hedestam GB, Wardemann H, Pulendran B, Doria-Rose NA, He WT, Juno JA, Ataca S, Wheatley AK, McLellan JS, Walker LM, Lederhofer J, Lindesmith LC, Wille H, Hotez PJ, Bekker LG. Progress in vaccine development for infectious diseases-a Keystone Symposia report. Ann N Y Acad Sci. 2023 Jun;1524(1):65-86. doi: 10.1111/nyas.14975. Epub 2023 Apr 5. PMID: 37020354.

Tritz ZP, Ayasoufi K, Wolf DM, Owens CA, Malo CS, Himes BT, Fain CE, Goddery EN, Yokanovich LT, Jin F, Hansen MJ, Parney IF, Wang C, Moynihan KD, Irvine DJ, Wittrup KD, Diaz Marcano RM, Vile RG, Johnson AJ. Anti-PD-1 and Extended Half- life IL2 Synergize for Treatment of Murine Glioblastoma Independent of Host MHC Class I Expression. Cancer Immunol Res. 2023 Jun 2;11(6):763-776. doi: 10.1158/2326-6066.CIR-22-0570. PMID: 36921098; PMCID: PMC10239322.

Du S, Li W, Zhang Y, Xue Y, Hou X, Yan J, Cheng J, Deng B, McComb DW, Lin J, Zeng H, Cheng X, Irvine DJ, Weiss R, Dong Y. Cholesterol-Amino-Phosphate (CAP) Derived Lipid Nanoparticles for Delivery of Self-Amplifying RNA and Restoration of Spermatogenesis in Infertile Mice. Adv Sci (Weinh). 2023 Apr;10(11):e2300188. doi: 10.1002/advs.202300188. Epub 2023 Feb 7. Erratum in: Adv Sci (Weinh). 2024 Dec;11(45):e2412632. doi: 10.1002/advs.202412632. PMID: 36748274; PMCID: PMC10104632.

Lee JH, Sutton HJ, Cottrell CA, Phung I, Ozorowski G, Sewall LM, Nedellec R, Nakao C, Silva M, Richey ST, Torres JL, Lee WH, Georgeson E, Kubitz M, Hodges S, Mullen TM, Adachi Y, Cirelli KM, Kaur A, Allers C, Fahlberg M, Grasperge BF, Dufour JP, Schiro F, Aye PP, Kalyuzhniy O, Liguori A, Carnathan DG, Silvestri G, Shen X, Montefiori DC, Veazey RS, Ward AB, Hangartner L, Burton DR, Irvine DJ, Schief WR, Crotty S. Author Correction: Long-primed germinal centres with enduring affinity maturation and clonal migration. Nature. 2023 Feb;614(7949):E43. doi: 10.1038/s41586-023-05741-1. Erratum for: Nature. 2022 Sep;609(7929):998-1004. doi: 10.1038/s41586-022-05216-9. PMID: 36717721; PMCID: PMC9885408.

Aung A, Cui A, Maiorino L, Amini AP, Gregory JR, Bukenya M, Zhang Y, Lee H, Cottrell CA, Morgan DM, Silva M, Suh H, Kirkpatrick JD, Amlashi P, Remba T, Froehle LM, Xiao S, Abraham W, Adams J, Love JC, Huyett P, Kwon DS, Hacohen N, Schief WR, Bhatia SN, Irvine DJ. Low protease activity in B cell follicles promotes retention of intact antigens after immunization. Science. 2023 Jan 27;379(6630):eabn8934. doi: 10.1126/science.abn8934. Epub 2023 Jan 27. PMID: 36701450; PMCID: PMC10041875.

Backlund C, Jalili-Firoozinezhad S, Kim B, Irvine DJ. Biomaterials-Mediated Engineering of the Immune System. Annu Rev Immunol. 2023 Apr 26;41:153-179. doi: 10.1146/annurev-immunol-101721-040259. Epub 2023 Jan 25. PMID: 36696570; PMCID: PMC10375298.

Barberio AE, Smith SG, Pires IS, Iyer S, Reinhardt F, Melo MB, Suh H, Weinberg RA, Irvine DJ, Hammond PT. Layer-by-layer interleukin-12 nanoparticles drive a safe and effective response in ovarian tumors. Bioeng Transl Med. 2022 Dec 1;8(2):e10453. doi: 10.1002/btm2.10453. PMID: 36925719; PMCID: PMC10013828.

Gordon KS, Kyung T, Perez CR, Holec PV, Ramos A, Zhang AQ, Agarwal Y, Liu Y, Koch CE, Starchenko A, Joughin BA, Lauffenburger DA, Irvine DJ, Hemann MT, Birnbaum ME. Author Correction: Screening for CD19-specific chimaeric antigen receptors with enhanced signalling via a barcoded library of intracellular domains. Nat Biomed Eng. 2023 Apr;7(4):599-602. doi: 10.1038/s41551-023-01006-4. Erratum for: Nat Biomed Eng. 2022 Jul;6(7):855-866. doi: 10.1038/s41551-022-00896-0. PMID: 36737667.

Irvine DJ, Maus MV, Mooney DJ, Wong WW. The future of engineered immune cell therapies. Science. 2022 Nov 25;378(6622):853-858. doi: 10.1126/science.abq6990. Epub 2022 Nov 24. PMID: 36423279; PMCID: PMC9919886.

Kim B, Hosn RR, Remba T, Yun D, Li N, Abraham W, Melo MB, Cortes M, Li B, Zhang Y, Dong Y, Irvine DJ. Optimization of storage conditions for lipid nanoparticle-formulated self-replicating RNA vaccines. J Control Release. 2023 Jan;353:241-253. doi: 10.1016/j.jconrel.2022.11.022. Epub 2022 Nov 30. PMID: 36414195; PMCID: PMC9708520.

Chang JYH, Agarwal Y, Rodrigues KA, Momin N, Ni K, Read BJ, Moyer TJ, Mehta NK, Silva M, Suh H, Melo MB, Wittrup KD, Irvine DJ. Co-Anchoring of Engineered Immunogen and Immunostimulatory Cytokines to Alum Promotes Enhanced-Humoral Immunity. Adv Ther (Weinh). 2022 Jul;5(7):2100235. doi: 10.1002/adtp.202100235. Epub 2022 Apr 7. PMID: 36311814; PMCID: PMC9595138.

Lee JH, Sutton HJ, Cottrell CA, Phung I, Ozorowski G, Sewall LM, Nedellec R, Nakao C, Silva M, Richey ST, Torres JL, Lee WH, Georgeson E, Kubitz M, Hodges S, Mullen TM, Adachi Y, Cirelli KM, Kaur A, Allers C, Fahlberg M, Grasperge BF, Dufour JP, Schiro F, Aye PP, Kalyuzhniy O, Liguori A, Carnathan DG, Silvestri G, Shen X, Montefiori DC, Veazey RS, Ward AB, Hangartner L, Burton DR, Irvine DJ, Schief WR, Crotty S. Long-primed germinal centres with enduring affinity maturation and clonal migration. Nature. 2022 Sep;609(7929):998-1004. doi: 10.1038/s41586-022-05216-9. Epub 2022 Sep 21. Erratum in: Nature. 2023 Feb;614(7949):E43. doi: 10.1038/s41586-023-05741-1. PMID: 36131022; PMCID: PMC9491273.

Lutz EA, Agarwal Y, Momin N, Cowles SC, Palmeri JR, Duong E, Hornet V, Sheen A, Lax BM, Rothschilds AM, Irvine DJ, Spranger S, Wittrup KD. Alum-anchored intratumoral retention improves the tolerability and antitumor efficacy of type I interferon therapies. Proc Natl Acad Sci U S A. 2022 Sep 6;119(36):e2205983119. doi: 10.1073/pnas.2205983119. Epub 2022 Aug 29. PMID: 36037341; PMCID: PMC9457244.

He WT, Yuan M, Callaghan S, Musharrafieh R, Song G, Silva M, Beutler N, Lee WH, Yong P, Torres JL, Melo M, Zhou P, Zhao F, Zhu X, Peng L, Huang D, Anzanello F, Ricketts J, Parren M, Garcia E, Ferguson M, Rinaldi W, Rawlings SA, Nemazee D, Smith DM, Briney B, Safonova Y, Rogers TF, Dan JM, Zhang Z, Weiskopf D, Sette A, Crotty S, Irvine DJ, Ward AB, Wilson IA, Burton DR, Andrabi R. Broadly neutralizing antibodies to SARS-related viruses can be readily induced in rhesus macaques. Sci Transl Med. 2022 Aug 10;14(657):eabl9605. doi: 10.1126/scitranslmed.abl9605. Epub 2022 Aug 10. PMID: 35947674; PMCID: PMC10069796.

Backlund CM, Holden RL, Moynihan KD, Garafola D, Farquhar C, Mehta NK, Maiorino L, Pham S, Iorgulescu JB, Reardon DA, Wu CJ, Pentelute BL, Irvine DJ. Cell-penetrating peptides enhance peptide vaccine accumulation and persistence in lymph nodes to drive immunogenicity. Proc Natl Acad Sci U S A. 2022 Aug 9;119(32):e2204078119. doi: 10.1073/pnas.2204078119. Epub 2022 Aug 1. PMID: 35914154; PMCID: PMC9371699.

Hartwell BL, Melo MB, Xiao P, Lemnios AA, Li N, Chang JYH, Yu J, Gebre MS, Chang A, Maiorino L, Carter C, Moyer TJ, Dalvie NC, Rodriguez-Aponte SA, Rodrigues KA, Silva M, Suh H, Adams J, Fontenot J, Love JC, Barouch DH, Villinger F, Ruprecht RM, Irvine DJ. Intranasal vaccination with lipid- conjugated immunogens promotes antigen transmucosal uptake to drive mucosal and systemic immunity. Sci Transl Med. 2022 Jul 20;14(654):eabn1413. doi: 10.1126/scitranslmed.abn1413. Epub 2022 Jul 20. PMID: 35857825; PMCID: PMC9835395.

Grace BE, Backlund CM, Morgan DM, Kang BH, Singh NK, Huisman BD, Rappazzo CG, Moynihan KD, Maiorino L, Dobson CS, Kyung T, Gordon KS, Holec PV, Mbah OCT, Garafola D, Wu S, Love JC, Wittrup KD, Irvine DJ, Birnbaum ME. Identification of Highly Cross-Reactive Mimotopes for a Public T Cell Response in Murine Melanoma. Front Immunol. 2022 Jun 23;13:886683. doi: 10.3389/fimmu.2022.886683. PMID: 35812387; PMCID: PMC9260506.

Gordon KS, Kyung T, Perez CR, Holec PV, Ramos A, Zhang AQ, Agarwal Y, Liu Y, Koch CE, Starchenko A, Joughin BA, Lauffenburger DA, Irvine DJ, Hemann MT, Birnbaum ME. Screening for CD19-specific chimaeric antigen receptors with enhanced signalling via a barcoded library of intracellular domains. Nat Biomed Eng. 2022 Jul;6(7):855-866. doi: 10.1038/s41551-022-00896-0. Epub 2022 Jun 16. Erratum in: Nat Biomed Eng. 2023 Apr;7(4):599-602. doi: 10.1038/s41551-023-01006-4. PMID: 35710755; PMCID: PMC9389442.

He Y, Hong C, Fletcher SJ, Berger AG, Sun X, Yang M, Huang S, Belcher AM, Irvine DJ, Li J, Hammond PT. Peptide-Based Cancer Vaccine Delivery via the STINGΔTM-cGAMP Complex. Adv Healthc Mater. 2022 Aug;11(15):e2200905. doi: 10.1002/adhm.202200905. Epub 2022 Jun 19. PMID: 35670244; PMCID: PMC11117022.

Wamhoff EC, Romanov A, Huang H, Read BJ, Ginsburg E, Knappe GA, Kim HM, Farrell NP, Irvine DJ, Bathe M. Controlling Nuclease Degradation of Wireframe DNA Origami with Minor Groove Binders. ACS Nano. 2022 Jun 28;16(6):8954-8966. doi: 10.1021/acsnano.1c11575. Epub 2022 May 31. PMID: 35640255; PMCID: PMC9649841.

Wittrup KD, Kaufman HL, Schmidt MM, Irvine DJ. Intratumorally anchored cytokine therapy. Expert Opin Drug Deliv. 2022 Jun;19(6):725-732. doi: 10.1080/17425247.2022.2084070. Epub 2022 Jun 2. PMID: 35638290; PMCID: PMC9262866.

Dane EL, Belessiotis-Richards A, Backlund C, Wang J, Hidaka K, Milling LE, Bhagchandani S, Melo MB, Wu S, Li N, Donahue N, Ni K, Ma L, Okaniwa M, Stevens MM, Alexander-Katz A, Irvine DJ. STING agonist delivery by tumour-penetrating PEG-lipid nanodiscs primes robust anticancer immunity. Nat Mater. 2022 Jun;21(6):710-720. doi: 10.1038/s41563-022-01251-z. Epub 2022 May 23. PMID: 35606429; PMCID: PMC9156412.

Sriram G, Emmons TR, Milling LE, Irvine DJ, Yaffe MB. Immunogenic cell stress and injury versus immunogenic cell death: implications for improving cancer treatment with immune checkpoint blockade. Mol Cell Oncol. 2022 Apr 3;9(1):2039038. doi: 10.1080/23723556.2022.2039038. PMID: 35402699; PMCID: PMC8986242.

Sahoo A, Hodge EA, LaBranche CC, Styles TM, Shen X, Cheedarla N, Shiferaw A, Ozorowski G, Lee WH, Ward AB, Tomaras GD, Montefiori DC, Irvine DJ, Lee KK, Amara RR. Structure-guided changes at the V2 apex of HIV-1 clade C trimer enhance elicitation of autologous neutralizing and broad V1V2-scaffold antibodies. Cell Rep. 2022 Mar 1;38(9):110436. doi: 10.1016/j.celrep.2022.110436. PMID: 35235790; PMCID: PMC8982139.

Borriello F, Poli V, Shrock E, Spreafico R, Liu X, Pishesha N, Carpenet C, Chou J, Di Gioia M, McGrath ME, Dillen CA, Barrett NA, Lacanfora L, Franco ME, Marongiu L, Iwakura Y, Pucci F, Kruppa MD, Ma Z, Lowman DW, Ensley HE, Nanishi E, Saito Y, O’Meara TR, Seo HS, Dhe-Paganon S, Dowling DJ, Frieman M, Elledge SJ, Levy O, Irvine DJ, Ploegh HL, Williams DL, Zanoni I. An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity. Cell. 2022 Feb 17;185(4):614-629.e21. doi: 10.1016/j.cell.2022.01.009. Epub 2022 Feb 10. PMID: 35148840; PMCID: PMC8857056.

Read BJ, Won L, Kraft JC, Sappington I, Aung A, Wu S, Bals J, Chen C, Lee KK, Lingwood D, King NP, Irvine DJ. Mannose-binding lectin and complement mediate follicular localization and enhanced immunogenicity of diverse protein nanoparticle immunogens. Cell Rep. 2022 Jan 11;38(2):110217. doi: 10.1016/j.celrep.2021.110217. PMID: 35021101; PMCID: PMC8805147.

Agarwal Y, Milling LE, Chang JYH, Santollani L, Sheen A, Lutz EA, Tabet A, Stinson J, Ni K, Rodrigues KA, Moyer TJ, Melo MB, Irvine DJ, Wittrup KD. Intratumourally injected alum-tethered cytokines elicit potent and safer local and systemic anticancer immunity. Nat Biomed Eng. 2022 Feb;6(2):129-143. doi: 10.1038/s41551-021-00831-9. Epub 2022 Jan 10. PMID: 35013574; PMCID: PMC9681025.

Brewer JM, Irvine DJ. Introduction to the Special Issue: Nanoparticles and immune responses. Semin Immunol. 2021 Aug;56:101548. doi: 10.1016/j.smim.2021.101548. Epub 2021 Dec 10. PMID: 34903434.

Rodrigues KA, Rodriguez-Aponte SA, Dalvie NC, Lee JH, Abraham W, Carnathan DG, Jimenez LE, Ngo JT, Chang JYH, Zhang Z, Yu J, Chang A, Nakao C, Goodwin B, Naranjo CA, Zhang L, Silva M, Barouch DH, Silvestri G, Crotty S, Love JC, Irvine DJ. Phosphate-mediated coanchoring of RBD immunogens and molecular adjuvants to alum potentiates humoral immunity against SARS-CoV-2. Sci Adv. 2021 Dec 10;7(50):eabj6538. doi: 10.1126/sciadv.abj6538. Epub 2021 Dec 8. PMID: 34878851; PMCID: PMC8654298.

Silva M, Kato Y, Melo MB, Phung I, Freeman BL, Li Z, Roh K, Van Wijnbergen JW, Watkins H, Enemuo CA, Hartwell BL, Chang JYH, Xiao S, Rodrigues KA, Cirelli KM, Li N, Haupt S, Aung A, Cossette B, Abraham W, Kataria S, Bastidas R, Bhiman J, Linde C, Bloom NI, Groschel B, Georgeson E, Phelps N, Thomas A, Bals J, Carnathan DG, Lingwood D, Burton DR, Alter G, Padera TP, Belcher AM, Schief WR, Silvestri G, Ruprecht RM, Crotty S, Irvine DJ. A particulate saponin/TLR agonist vaccine adjuvant alters lymph flow and modulates adaptive immunity. Sci Immunol. 2021 Dec 3;6(66):eabf1152. doi: 10.1126/sciimmunol.abf1152. Epub 2021 Dec 3. PMID: 34860581; PMCID: PMC8763571.

Wang C, Cui A, Bukenya M, Aung A, Pradhan D, Whittaker CA, Agarwal Y, Thomas A, Liang S, Amlashi P, Suh H, Spranger S, Hacohen N, Irvine DJ. Reprogramming NK cells and macrophages via combined antibody and cytokine therapy primes tumors for elimination by checkpoint blockade. Cell Rep. 2021 Nov 23;37(8):110021. doi: 10.1016/j.celrep.2021.110021. PMID: 34818534; PMCID: PMC8653865.

Escolano A, Gristick HB, Gautam R, DeLaitsch AT, Abernathy ME, Yang Z, Wang H, Hoffmann MAG, Nishimura Y, Wang Z, Koranda N, Kakutani LM, Gao H, Gnanapragasam PNP, Raina H, Gazumyan A, Cipolla M, Oliveira TY, Ramos V, Irvine DJ, Silva M, West AP Jr, Keeffe JR, Barnes CO, Seaman MS, Nussenzweig MC, Martin MA, Bjorkman PJ. Sequential immunization of macaques elicits heterologous neutralizing antibodies targeting the V3-glycan patch of HIV-1 Env. Sci Transl Med. 2021 Nov 24;13(621):eabk1533. doi: 10.1126/scitranslmed.abk1533. Epub 2021 Nov 24. PMID: 34818054; PMCID: PMC8932345.

Westcott PMK, Sacks NJ, Schenkel JM, Ely ZA, Smith O, Hauck H, Jaeger AM, Zhang D, Backlund CM, Beytagh MC, Patten JJ, Elbashir R, Eng G, Irvine DJ, Yilmaz OH, Jacks T. Low neoantigen expression and poor T-cell priming underlie early immune escape in colorectal cancer. Nat Cancer. 2021 Oct;2(10):1071-1085. doi: 10.1038/s43018-021-00247-z. Epub 2021 Sep 30. PMID: 34738089; PMCID: PMC8562866.

Pires IS, Hammond PT, Irvine DJ. Engineering Strategies for Immunomodulatory Cytokine Therapies – Challenges and Clinical Progress. Adv Ther (Weinh). 2021 Aug;4(8):2100035. doi: 10.1002/adtp.202100035. Epub 2021 Apr 2. PMID: 34734110; PMCID: PMC8562465.

Milling LE, Garafola D, Agarwal Y, Wu S, Thomas A, Donahue N, Adams J, Thai N, Suh H, Irvine DJ. Neoadjuvant STING Activation, Extended Half-life IL2, and Checkpoint Blockade Promote Metastasis Clearance via Sustained NK-cell Activation. Cancer Immunol Res. 2022 Jan;10(1):26-39. doi: 10.1158/2326-6066.CIR-21-0247. Epub 2021 Oct 22. PMID: 34686488; PMCID: PMC8732307.

Sriram G, Milling LE, Chen JK, Kong YW, Joughin BA, Abraham W, Swartwout S, Handly ED, Irvine DJ, Yaffe MB. The injury response to DNA damage in live tumor cells promotes antitumor immunity. Sci Signal. 2021 Oct 19;14(705):eabc4764. doi: 10.1126/scisignal.abc4764. Epub 2021 Oct 19. PMID: 34665642; PMCID: PMC8791539.

Dalvie NC, Rodriguez-Aponte SA, Hartwell BL, Tostanoski LH, Biedermann AM, Crowell LE, Kaur K, Kumru OS, Carter L, Yu J, Chang A, McMahan K, Courant T, Lebas C, Lemnios AA, Rodrigues KA, Silva M, Johnston RS, Naranjo CA, Tracey MK, Brady JR, Whittaker CA, Yun D, Brunette N, Wang JY, Walkey C, Fiala B, Kar S, Porto M, Lok M, Andersen H, Lewis MG, Love KR, Camp DL, Silverman JM, Kleanthous H, Joshi SB, Volkin DB, Dubois PM, Collin N, King NP, Barouch DH, Irvine DJ, Love JC. Engineered SARS-CoV-2 receptor binding domain improves manufacturability in yeast and immunogenicity in mice. Proc Natl Acad Sci U S A. 2021 Sep 21;118(38):e2106845118. doi: 10.1073/pnas.2106845118. PMID: 34493582; PMCID: PMC8463846.

Knappe GA, Wamhoff EC, Read BJ, Irvine DJ, Bathe M. In Situ Covalent Functionalization of DNA Origami Virus-like Particles. ACS Nano. 2021 Sep 28;15(9):14316-14322. doi: 10.1021/acsnano.1c03158. Epub 2021 Sep 7. PMID: 34490781; PMCID: PMC8628367.

Loftis AR, Zhang G, Backlund C, Quartararo AJ, Pishesha N, Hanna CC, Schissel CK, Garafola D, Loas A, Collier RJ, Ploegh H, Irvine DJ, Pentelute BL. An in vivo selection-derived d-peptide for engineering erythrocyte-binding antigens that promote immune tolerance. Proc Natl Acad Sci U S A. 2021 Aug 24;118(34):e2101596118. doi: 10.1073/pnas.2101596118. PMID: 34417313; PMCID: PMC8403921.

Turner HL, Andrabi R, Cottrell CA, Richey ST, Song G, Callaghan S, Anzanello F, Moyer TJ, Abraham W, Melo M, Silva M, Scaringi N, Rakasz EG, Sattentau QJ, Irvine DJ, Burton DR, Ward AB. Disassembly of HIV envelope glycoprotein trimer immunogens is driven by antibodies elicited via immunization. Sci Adv. 2021 Jul 28;7(31):eabh2791. doi: 10.1126/sciadv.abh2791. PMID: 34321200; PMCID: PMC8318364.

Martin JT, Hartwell BL, Kumarapperuma SC, Melo MB, Carnathan DG, Cossette BJ, Adams J, Gong S, Zhang W, Tokatlian T, Menis S, Schiffner T, Franklin CG, Goins B, Fox PT, Silvestri G, Schief WR, Ruprecht RM, Irvine DJ. Combined PET and whole-tissue imaging of lymphatic-targeting vaccines in non-human primates. Biomaterials. 2021 Aug;275:120868. doi: 10.1016/j.biomaterials.2021.120868. Epub 2021 May 14. PMID: 34091299; PMCID: PMC8325633.

Bhagchandani S, Johnson JA, Irvine DJ. Evolution of Toll-like receptor 7/8 agonist therapeutics and their delivery approaches: From antiviral formulations to vaccine adjuvants. Adv Drug Deliv Rev. 2021 Aug;175:113803. doi: 10.1016/j.addr.2021.05.013. Epub 2021 May 29. PMID: 34058283; PMCID: PMC9003539.

McCann CD, van Dorp CH, Danesh A, Ward AR, Dilling TR, Mota TM, Zale E, Stevenson EM, Patel S, Brumme CJ, Dong W, Jones DS, Andresen TL, Walker BD, Brumme ZL, Bollard CM, Perelson AS, Irvine DJ, Jones RB. A participant-derived xenograft model of HIV enables long-term evaluation of autologous immunotherapies. J Exp Med. 2021 Jul 5;218(7):e20201908. doi: 10.1084/jem.20201908. Epub 2021 May 14. PMID: 33988715; PMCID: PMC8129803.

Chang JYH, Irvine DJ. Engineering autoreactive T and B cell responses toward active immunotherapy for inflammatory diseases. Proc Natl Acad Sci U S A. 2021 May 18;118(20):e2104743118. doi: 10.1073/pnas.2104743118. PMID: 33883270; PMCID: PMC8157984.

Kang BH, Momin N, Moynihan KD, Silva M, Li Y, Irvine DJ, Wittrup KD. Immunotherapy-induced antibodies to endogenous retroviral envelope glycoprotein confer tumor protection in mice. PLoS One. 2021 Apr 15;16(4):e0248903. doi: 10.1371/journal.pone.0248903. PMID: 33857179; PMCID: PMC8049297.

Steinbach S, Jalili-Firoozinezhad S, Srinivasan S, Melo MB, Middleton S, Konold T, Coad M, Hammond PT, Irvine DJ, Vordermeier M, Kapur V. Temporal dynamics of intradermal cytokine response to tuberculin in Mycobacterium bovis BCG-vaccinated cattle using sampling microneedles. Sci Rep. 2021 Mar 29;11(1):7074. doi: 10.1038/s41598-021-86398-6. PMID: 33782422; PMCID: PMC8007627.

Rakhra K, Abraham W, Wang C, Moynihan KD, Li N, Donahue N, Baldeon AD, Irvine DJ. Exploiting albumin as a mucosal vaccine chaperone for robust generation of lung-resident memory T cells. Sci Immunol. 2021 Mar 19;6(57):eabd8003. doi: 10.1126/sciimmunol.abd8003. PMID: 33741657; PMCID: PMC8279396.

He Y, Hong C, Irvine DJ, Li J, Hammond PT. In vitro STING Activation with the cGAMP-STINGΔTM Signaling Complex. Bio Protoc. 2021 Feb 5;11(3):e3905. doi: 10.21769/BioProtoc.3905. PMID: 33732792; PMCID: PMC7952947.

Lu Z, Truex NL, Melo MB, Cheng Y, Li N, Irvine DJ, Pentelute BL. IgG- Engineered Protective Antigen for Cytosolic Delivery of Proteins into Cancer Cells. ACS Cent Sci. 2021 Feb 24;7(2):365-378. doi: 10.1021/acscentsci.0c01670. Epub 2021 Feb 4. PMID: 33655074; PMCID: PMC7908032.

Draganov D, Han Z, Rana A, Bennett N, Irvine DJ, Lee PP. Ivermectin converts cold tumors hot and synergizes with immune checkpoint blockade for treatment of breast cancer. NPJ Breast Cancer. 2021 Mar 2;7(1):22. doi: 10.1038/s41523-021-00229-5. PMID: 33654071; PMCID: PMC7925581.

Huang S, Lin CW, Qi J, Iyer AM, He Y, Li Y, Bardhan NM, Irvine DJ, Hammond PT, Belcher AM. Surface Plasmon-Enhanced Short-Wave Infrared Fluorescence for Detecting Sub-Millimeter-Sized Tumors. Adv Mater. 2021 Feb;33(7):e2006057. doi: 10.1002/adma.202006057. Epub 2021 Jan 14. PMID: 33448062.

Mc Cafferty S, De Temmerman J, Kitada T, Becraft JR, Weiss R, Irvine DJ, Devreese M, De Baere S, Combes F, Sanders NN. In Vivo Validation of a Reversible Small Molecule-Based Switch for Synthetic Self-Amplifying mRNA Regulation. Mol Ther. 2021 Mar 3;29(3):1164-1173. doi: 10.1016/j.ymthe.2020.11.010. Epub 2020 Nov 11. PMID: 33186690; PMCID: PMC7934578.

Li Y, Su Z, Zhao W, Zhang X, Momin N, Zhang C, Wittrup KD, Dong Y, Irvine DJ, Weiss R. Multifunctional oncolytic nanoparticles deliver self-replicating IL-12 RNA to eliminate established tumors and prime systemic immunity. Nat Cancer. 2020 Sep;1(9):882-893. doi: 10.1038/s43018-020-0095-6. Epub 2020 Aug 10. PMID: 34447945; PMCID: PMC8386348.

Vohidov F, Milling LE, Chen Q, Zhang W, Bhagchandani S, Nguyen HV, Irvine DJ, Johnson JA. ABC triblock bottlebrush copolymer-based injectable hydrogels: design, synthesis, and application to expanding the therapeutic index of cancer immunochemotherapy. Chem Sci. 2020 Jun 1;11(23):5974-5986. doi: 10.1039/d0sc02611e. PMID: 34094088; PMCID: PMC8159417.

Eskandari SK, Sulkaj I, Melo MB, Li N, Allos H, Alhaddad JB, Kollar B, Borges TJ, Eskandari AS, Zinter MA, Cai S, Assaker JP, Choi JY, Al Dulaijan BS, Mansouri A, Haik Y, Tannous BA, van Son WJ, Leuvenink HGD, Pomahac B, Riella LV, Tang L, Seelen MAJ, Irvine DJ, Azzi JR. Regulatory T cells engineered with TCR signaling-responsive IL-2 nanogels suppress alloimmunity in sites of antigen encounter. Sci Transl Med. 2020 Nov 11;12(569):eaaw4744. doi: 10.1126/scitranslmed.aaw4744. PMID: 33177180; PMCID: PMC8519505.

Kato Y, Abbott RK, Freeman BL, Haupt S, Groschel B, Silva M, Menis S, Irvine DJ, Schief WR, Crotty S. Multifaceted Effects of Antigen Valency on B Cell Response Composition and Differentiation In Vivo. Immunity. 2020 Sep 15;53(3):548-563.e8. doi: 10.1016/j.immuni.2020.08.001. Epub 2020 Aug 27. PMID: 32857950; PMCID: PMC7451196.

Martin JT, Cottrell CA, Antanasijevic A, Carnathan DG, Cossette BJ, Enemuo CA, Gebru EH, Choe Y, Viviano F, Fischinger S, Tokatlian T, Cirelli KM, Ueda G, Copps J, Schiffner T, Menis S, Alter G, Schief WR, Crotty S, King NP, Baker D, Silvestri G, Ward AB, Irvine DJ. Targeting HIV Env immunogens to B cell follicles in nonhuman primates through immune complex or protein nanoparticle formulations. NPJ Vaccines. 2020 Aug 5;5(1):72. doi: 10.1038/s41541-020-00223-1. PMID: 32802411; PMCID: PMC7406516.

Barberio AE, Smith SG, Correa S, Nguyen C, Nhan B, Melo M, Tokatlian T, Suh H, Irvine DJ, Hammond PT. Cancer Cell Coating Nanoparticles for Optimal Tumor- Specific Cytokine Delivery. ACS Nano. 2020 Sep 22;14(9):11238-11253. doi: 10.1021/acsnano.0c03109. Epub 2020 Sep 5. PMID: 32692155; PMCID: PMC7530125.

Tahir MA, Guven ZP, Arriaga LR, Tinao B, Yang YS, Bekdemir A, Martin JT, Bhanji AN, Irvine D, Stellacci F, Alexander-Katz A. Calcium-triggered fusion of lipid membranes is enabled by amphiphilic nanoparticles. Proc Natl Acad Sci U S A. 2020 Aug 4;117(31):18470-18476. doi: 10.1073/pnas.1902597117. Epub 2020 Jul 20. PMID: 32690682; PMCID: PMC7414053.

Andrews LP, Somasundaram A, Moskovitz JM, Szymczak-Workman AL, Liu C, Cillo AR, Lin H, Normolle DP, Moynihan KD, Taniuchi I, Irvine DJ, Kirkwood JM, Lipson EJ, Ferris RL, Bruno TC, Workman CJ, Vignali DAA. Resistance to PD1 blockade in the absence of metalloprotease-mediated LAG3 shedding. Sci Immunol. 2020 Jul 17;5(49):eabc2728. doi: 10.1126/sciimmunol.abc2728. PMID: 32680952; PMCID: PMC7901539.

Veneziano R, Moyer TJ, Stone MB, Wamhoff EC, Read BJ, Mukherjee S, Shepherd TR, Das J, Schief WR, Irvine DJ, Bathe M. Role of nanoscale antigen organization on B-cell activation probed using DNA origami. Nat Nanotechnol. 2020 Aug;15(8):716-723. doi: 10.1038/s41565-020-0719-0. Epub 2020 Jun 29. PMID: 32601450; PMCID: PMC7415668.

Irvine DJ, Aung A, Silva M. Controlling timing and location in vaccines. Adv Drug Deliv Rev. 2020;158:91-115. doi: 10.1016/j.addr.2020.06.019. Epub 2020 Jun 26. PMID: 32598970; PMCID: PMC7318960.

He Y, Hong C, Yan EZ, Fletcher SJ, Zhu G, Yang M, Li Y, Sun X, Irvine DJ, Li J, Hammond PT. Self-assembled cGAMP-STINGΔTM signaling complex as a bioinspired platform for cGAMP delivery. Sci Adv. 2020 Jun 12;6(24):eaba7589. doi: 10.1126/sciadv.aba7589. PMID: 32582856; PMCID: PMC7292616.

Mehta NK, Pradhan RV, Soleimany AP, Moynihan KD, Rothschilds AM, Momin N, Rakhra K, Mata-Fink J, Bhatia SN, Wittrup KD, Irvine DJ. Pharmacokinetic tuning of protein-antigen fusions enhances the immunogenicity of T-cell vaccines. Nat Biomed Eng. 2020 Jun;4(6):636-648. doi: 10.1038/s41551-020-0563-4. Epub 2020 Jun 1. PMID: 32483299; PMCID: PMC7575059.

Moyer TJ, Kato Y, Abraham W, Chang JYH, Kulp DW, Watson N, Turner HL, Menis S, Abbott RK, Bhiman JN, Melo MB, Simon HA, Herrera-De la Mata S, Liang S, Seumois G, Agarwal Y, Li N, Burton DR, Ward AB, Schief WR, Crotty S, Irvine DJ. Author Correction: A Engineered immunogen binding to alum adjuvant enhances humoral immunity. Nat Med. 2020 May;26(5):804. doi: 10.1038/s41591-020-0861-0. Erratum for: Nat Med. 2020 Mar;26(3):430-440. doi: 10.1038/s41591-020-0753-3. PMID: 32405059; PMCID: PMC7223225.

Irvine DJ, Read BJ. Shaping humoral immunity to vaccines through antigen- displaying nanoparticles. Curr Opin Immunol. 2020 Aug;65:1-6. doi: 10.1016/j.coi.2020.01.007. Epub 2020 Mar 19. PMID: 32200132; PMCID: PMC7501207.

Moyer TJ, Kato Y, Abraham W, Chang JYH, Kulp DW, Watson N, Turner HL, Menis S, Abbott RK, Bhiman JN, Melo MB, Simon HA, Herrera-De la Mata S, Liang S, Seumois G, Agarwal Y, Li N, Burton DR, Ward AB, Schief WR, Crotty S, Irvine DJ. Engineered immunogen binding to alum adjuvant enhances humoral immunity. Nat Med. 2020 Mar;26(3):430-440. doi: 10.1038/s41591-020-0753-3. Epub 2020 Feb 17. Erratum in: Nat Med. 2020 May;26(5):804. doi: 10.1038/s41591-020-0861-0. PMID: 32066977; PMCID: PMC7069805.

Irvine DJ, Dane EL. Enhancing cancer immunotherapy with nanomedicine. Nat Rev Immunol. 2020 May;20(5):321-334. doi: 10.1038/s41577-019-0269-6. Epub 2020 Jan 31. PMID: 32005979; PMCID: PMC7536618.

Cirelli KM, Carnathan DG, Nogal B, Martin JT, Rodriguez OL, Upadhyay AA, Enemuo CA, Gebru EH, Choe Y, Viviano F, Nakao C, Pauthner MG, Reiss S, Cottrell CA, Smith ML, Bastidas R, Gibson W, Wolabaugh AN, Melo MB, Cossette B, Kumar V, Patel NB, Tokatlian T, Menis S, Kulp DW, Burton DR, Murrell B, Schief WR, Bosinger SE, Ward AB, Watson CT, Silvestri G, Irvine DJ, Crotty S. Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance. Cell. 2020 Jan 9;180(1):206. doi: 10.1016/j.cell.2019.12.027. Erratum for: Cell. 2019 May 16;177(5):1153-1171.e28. doi: 10.1016/j.cell.2019.04.012. PMID: 31923396; PMCID: PMC7009795.

Kumari S, Mak M, Poh YC, Tohme M, Watson N, Melo M, Janssen E, Dustin M, Geha R, Irvine DJ. Cytoskeletal tension actively sustains the migratory T-cell synaptic contact. EMBO J. 2020 Mar 2;39(5):e102783. doi: 10.15252/embj.2019102783. Epub 2020 Jan 2. PMID: 31894880; PMCID: PMC7049817.

Gilfillan CB, Wang C, Mohsen MO, Rufer N, Hebeisen M, Allard M, Verdeil G, Irvine DJ, Bachmann MF, Speiser DE. Murine CD8 T-cell functional avidity is stable in vivo but not in vitro: Independence from homologous prime/boost time interval and antigen density. Eur J Immunol. 2020 Apr;50(4):505-514. doi: 10.1002/eji.201948355. Epub 2019 Dec 10. PMID: 31785153; PMCID: PMC7187562.

Mahajan VS, Demissie E, Alsufyani F, Kumari S, Yuen GJ, Viswanadham V, Huang A, Tran JQ, Moon JJ, Irvine DJ, Pillai S. DOCK2 Sets the Threshold for Entry into the Virtual Memory CD8+ T Cell Compartment by Negatively Regulating Tonic TCR Triggering. J Immunol. 2020 Jan 1;204(1):49-57. doi: 10.4049/jimmunol.1900440. Epub 2019 Nov 18. PMID: 31740487; PMCID: PMC6920543.

Havenar-Daughton C, Carnathan DG, Boopathy AV, Upadhyay AA, Murrell B, Reiss SM, Enemuo CA, Gebru EH, Choe Y, Dhadvai P, Viviano F, Kaushik K, Bhiman JN, Briney B, Burton DR, Bosinger SE, Schief WR, Irvine DJ, Silvestri G, Crotty S. Rapid Germinal Center and Antibody Responses in Non-human Primates after a Single Nanoparticle Vaccine Immunization. Cell Rep. 2019 Nov 12;29(7):1756-1766.e8. doi: 10.1016/j.celrep.2019.10.008. PMID: 31722194; PMCID: PMC6905039.

Fotoran WL, Müntefering T, Kleiber N, Miranda BNM, Liebau E, Irvine DJ, Wunderlich G. A multilamellar nanoliposome stabilized by interlayer hydrogen bonds increases antimalarial drug efficacy. Nanomedicine. 2019 Nov;22:102099. doi: 10.1016/j.nano.2019.102099. Epub 2019 Oct 21. PMID: 31648039.

Kumari S, Colin-York H, Irvine DJ, Fritzsche M. Not All T Cell Synapses Are Built the Same Way. Trends Immunol. 2019 Nov;40(11):977-980. doi: 10.1016/j.it.2019.09.009. Epub 2019 Oct 20. PMID: 31645298; PMCID: PMC7322532.

Loukogeorgakis SP, Fachin CG, Dias AIBS, Li H, Tang L, Kim AG, Vrecenak JD, Stratigis JD, Ahn NJ, Nissim I, Nissim I, Moron AF, Martins JL, Peranteau WH, De Coppi P, Irvine DJ, Flake AW. Donor cell engineering with GSK3 inhibitor-loaded nanoparticles enhances engraftment after in utero transplantation. Blood. 2019 Nov 28;134(22):1983-1995. doi: 10.1182/blood.2019001037. PMID: 31570489.

Melo M, Porter E, Zhang Y, Silva M, Li N, Dobosh B, Liguori A, Skog P, Landais E, Menis S, Sok D, Nemazee D, Schief WR, Weiss R, Irvine DJ. Immunogenicity of RNA Replicons Encoding HIV Env Immunogens Designed for Self- Assembly into Nanoparticles. Mol Ther. 2019 Dec 4;27(12):2080-2090. doi: 10.1016/j.ymthe.2019.08.007. Epub 2019 Aug 19. PMID: 31515132; PMCID: PMC6904793.

Al Sulaiman D, Chang JYH, Bennett NR, Topouzi H, Higgins CA, Irvine DJ, Ladame S. Hydrogel-Coated Microneedle Arrays for Minimally Invasive Sampling and Sensing of Specific Circulating Nucleic Acids from Skin Interstitial Fluid. ACS Nano. 2019 Aug 27;13(8):9620-9628. doi: 10.1021/acsnano.9b04783. Epub 2019 Aug 16. PMID: 31411871; PMCID: PMC6746174.

Boopathy AV, Mandal A, Kulp DW, Menis S, Bennett NR, Watkins HC, Wang W, Martin JT, Thai NT, He Y, Schief WR, Hammond PT, Irvine DJ. Enhancing humoral immunity via sustained-release implantable microneedle patch vaccination. Proc Natl Acad Sci U S A. 2019 Aug 13;116(33):16473-16478. doi: 10.1073/pnas.1902179116. Epub 2019 Jul 29. PMID: 31358641; PMCID: PMC6697788.

Ma L, Dichwalkar T, Chang JYH, Cossette B, Garafola D, Zhang AQ, Fichter M, Wang C, Liang S, Silva M, Kumari S, Mehta NK, Abraham W, Thai N, Li N, Wittrup KD, Irvine DJ. Enhanced CAR-T cell activity against solid tumors by vaccine boosting through the chimeric receptor. Science. 2019 Jul 12;365(6449):162-168. doi: 10.1126/science.aav8692. PMID: 31296767; PMCID: PMC6800571.

Momin N, Mehta NK, Bennett NR, Ma L, Palmeri JR, Chinn MM, Lutz EA, Kang B, Irvine DJ, Spranger S, Wittrup KD. Anchoring of intratumorally administered cytokines to collagen safely potentiates systemic cancer immunotherapy. Sci Transl Med. 2019 Jun 26;11(498):eaaw2614. doi: 10.1126/scitranslmed.aaw2614. PMID: 31243150; PMCID: PMC7811803.

Escolano A, Gristick HB, Abernathy ME, Merkenschlager J, Gautam R, Oliveira TY, Pai J, West AP Jr, Barnes CO, Cohen AA, Wang H, Golijanin J, Yost D, Keeffe JR, Wang Z, Zhao P, Yao KH, Bauer J, Nogueira L, Gao H, Voll AV, Montefiori DC, Seaman MS, Gazumyan A, Silva M, McGuire AT, Stamatatos L, Irvine DJ, Wells L, Martin MA, Bjorkman PJ, Nussenzweig MC. Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques. Nature. 2019 Jun;570(7762):468-473. doi: 10.1038/s41586-019-1250-z. Epub 2019 May 29. PMID: 31142836; PMCID: PMC6657810.

Cirelli KM, Carnathan DG, Nogal B, Martin JT, Rodriguez OL, Upadhyay AA, Enemuo CA, Gebru EH, Choe Y, Viviano F, Nakao C, Pauthner MG, Reiss S, Cottrell CA, Smith ML, Bastidas R, Gibson W, Wolabaugh AN, Melo MB, Cossette B, Kumar V, Patel NB, Tokatlian T, Menis S, Kulp DW, Burton DR, Murrell B, Schief WR, Bosinger SE, Ward AB, Watson CT, Silvestri G, Irvine DJ, Crotty S. Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance. Cell. 2019 May 16;177(5):1153-1171.e28. doi: 10.1016/j.cell.2019.04.012. Epub 2019 May 9. Erratum in: Cell. 2020 Jan 9;180(1):206. doi: 10.1016/j.cell.2019.12.027. PMID: 31080066; PMCID: PMC6619430.

Rothschilds A, Tzeng A, Mehta NK, Moynihan KD, Irvine DJ, Wittrup KD. Order of administration of combination cytokine therapies can decouple toxicity from efficacy in syngeneic mouse tumor models. Oncoimmunology. 2019 Feb 19;8(5):e1558678. doi: 10.1080/2162402X.2018.1558678. PMID: 31069130; PMCID: PMC6492973.

Li Y, Teague B, Zhang Y, Su Z, Porter E, Dobosh B, Wagner T, Irvine DJ, Weiss R. In vitro evolution of enhanced RNA replicons for immunotherapy. Sci Rep. 2019 May 6;9(1):6932. doi: 10.1038/s41598-019-43422-0. PMID: 31061426; PMCID: PMC6502795.

Xie YQ , Arik H , Wei L , Zheng Y , Suh H , Irvine DJ , Tang L . Redox- responsive interleukin-2 nanogel specifically and safely promotes the proliferation and memory precursor differentiation of tumor-reactive T-cells. Biomater Sci. 2019 Mar 26;7(4):1345-1357. doi: 10.1039/c8bm01556b. PMID: 30698174; PMCID: PMC6435399.

Tokatlian T, Read BJ, Jones CA, Kulp DW, Menis S, Chang JYH, Steichen JM, Kumari S, Allen JD, Dane EL, Liguori A, Sangesland M, Lingwood D, Crispin M, Schief WR, Irvine DJ. Innate immune recognition of glycans targets HIV nanoparticle immunogens to germinal centers. Science. 2019 Feb 8;363(6427):649-654. doi: 10.1126/science.aat9120. Epub 2018 Dec 20. PMID: 30573546; PMCID: PMC6420719.

Pauthner MG, Nkolola JP, Havenar-Daughton C, Murrell B, Reiss SM, Bastidas R, Prévost J, Nedellec R, von Bredow B, Abbink P, Cottrell CA, Kulp DW, Tokatlian T, Nogal B, Bianchi M, Li H, Lee JH, Butera ST, Evans DT, Hangartner L, Finzi A, Wilson IA, Wyatt RT, Irvine DJ, Schief WR, Ward AB, Sanders RW, Crotty S, Shaw GM, Barouch DH, Burton DR. Vaccine-Induced Protection from Homologous Tier 2 SHIV Challenge in Nonhuman Primates Depends on Serum- Neutralizing Antibody Titers. Immunity. 2019 Jan 15;50(1):241-252.e6. doi: 10.1016/j.immuni.2018.11.011. Epub 2018 Dec 11. PMID: 30552025; PMCID: PMC6335502.

Yang YS , Moynihan KD , Bekdemir A , Dichwalkar TM , Noh MM , Watson N , Melo M , Ingram J , Suh H , Ploegh H , Stellacci FR , Irvine DJ . Targeting small molecule drugs to T cells with antibody-directed cell-penetrating gold nanoparticles. Biomater Sci. 2018 Dec 18;7(1):113-124. doi: 10.1039/c8bm01208c. PMID: 30444251; PMCID: PMC6310171.

Mandal A, Boopathy AV, Lam LKW, Moynihan KD, Welch ME, Bennett NR, Turvey ME, Thai N, Van JH, Love JC, Hammond PT, Irvine DJ. Cell and fluid sampling microneedle patches for monitoring skin-resident immunity. Sci Transl Med. 2018 Nov 14;10(467):eaar2227. doi: 10.1126/scitranslmed.aar2227. PMID: 30429353; PMCID: PMC11972007.

Mottas I, Bekdemir A, Cereghetti A, Spagnuolo L, Yang YS, Müller M, Irvine DJ, Stellacci F, Bourquin C. Amphiphilic nanoparticle delivery enhances the anticancer efficacy of a TLR7 ligand via local immune activation. Biomaterials. 2019 Jan;190-191:111-120. doi: 10.1016/j.biomaterials.2018.10.031. Epub 2018 Oct 25. PMID: 30415018.

Tokatlian T, Kulp DW, Mutafyan AA, Jones CA, Menis S, Georgeson E, Kubitz M, Zhang MH, Melo MB, Silva M, Yun DS, Schief WR, Irvine DJ. Enhancing Humoral Responses Against HIV Envelope Trimers via Nanoparticle Delivery with Stabilized Synthetic Liposomes. Sci Rep. 2018 Nov 8;8(1):16527. doi: 10.1038/s41598-018-34853-2. PMID: 30410003; PMCID: PMC6224390.

He Y, Hong C, Li J, Howard MT, Li Y, Turvey ME, Uppu DSSM, Martin JR, Zhang K, Irvine DJ, Hammond PT. Synthetic Charge-Invertible Polymer for Rapid and Complete Implantation of Layer-by-Layer Microneedle Drug Films for Enhanced Transdermal Vaccination. ACS Nano. 2018 Oct 23;12(10):10272-10280. doi: 10.1021/acsnano.8b05373. Epub 2018 Oct 4. PMID: 30272942; PMCID: PMC6501205.

Badamchi-Zadeh A, Moynihan KD, Larocca RA, Aid M, Provine NM, Iampietro MJ, Kinnear E, Penaloza-MacMaster P, Abbink P, Blass E, Tregoning JS, Irvine DJ, Barouch DH. Combined HDAC and BET Inhibition Enhances Melanoma Vaccine Immunogenicity and Efficacy. J Immunol. 2018 Nov 1;201(9):2744-2752. doi: 10.4049/jimmunol.1800885. Epub 2018 Sep 24. PMID: 30249811; PMCID: PMC6196294.

Deming TJ, Klok HA, Armes SP, Becker ML, Champion JA, Chen EY, Heilshorn SC, van Hest JCM, Irvine DJ, Johnson JA, Kiessling LL, Maynard HD, de la Cruz MO, Sullivan MO, Tirrell MV, Anseth KS, Lecommandoux S, Percec S, Zhong Z, Albertsson AC. Polymers at the Interface with Biology. Biomacromolecules. 2018 Aug 13;19(8):3151-3162. doi: 10.1021/acs.biomac.8b01029. PMID: 30099879.

Tang L, Zheng Y, Melo MB, Mabardi L, Castaño AP, Xie YQ, Li N, Kudchodkar SB, Wong HC, Jeng EK, Maus MV, Irvine DJ. Enhancing T cell therapy through TCR- signaling-responsive nanoparticle drug delivery. Nat Biotechnol. 2018 Sep;36(8):707-716. doi: 10.1038/nbt.4181. Epub 2018 Jul 9. PMID: 29985479; PMCID: PMC6078803.

Moynihan KD, Holden RL, Mehta NK, Wang C, Karver MR, Dinter J, Liang S, Abraham W, Melo MB, Zhang AQ, Li N, Gall SL, Pentelute BL, Irvine DJ. Enhancement of Peptide Vaccine Immunogenicity by Increasing Lymphatic Drainage and Boosting Serum Stability. Cancer Immunol Res. 2018 Sep;6(9):1025-1038. doi: 10.1158/2326-6066.CIR-17-0607. Epub 2018 Jun 18. PMID: 29915023; PMCID: PMC6247902.

Irvine D. Material aid for vaccines. Nat Mater. 2018 Jun;17(6):472-473. doi: 10.1038/s41563-018-0089-2. PMID: 29795221.

Atukorale PU, Guven ZP, Bekdemir A, Carney RP, Van Lehn RC, Yun DS, Jacob Silva PH, Demurtas D, Yang YS, Alexander-Katz A, Stellacci F, Irvine DJ. Structure-Property Relationships of Amphiphilic Nanoparticles That Penetrate or Fuse Lipid Membranes. Bioconjug Chem. 2018 Apr 18;29(4):1131-1140. doi: 10.1021/acs.bioconjchem.7b00777. Epub 2018 Feb 27. PMID: 29465986; PMCID: PMC6311100.

Zhang Y, Li N, Suh H, Irvine DJ. Nanoparticle anchoring targets immune agonists to tumors enabling anti-cancer immunity without systemic toxicity. Nat Commun. 2018 Jan 2;9(1):6. doi: 10.1038/s41467-017-02251-3. PMID: 29295974; PMCID: PMC5750237.

Schmid D, Park CG, Hartl CA, Subedi N, Cartwright AN, Puerto RB, Zheng Y, Maiarana J, Freeman GJ, Wucherpfennig KW, Irvine DJ, Goldberg MS. T cell- targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity. Nat Commun. 2017 Nov 23;8(1):1747. doi: 10.1038/s41467-017-01830-8. PMID: 29170511; PMCID: PMC5700944.

He Y, Li J, Turvey ME, Funkenbusch MT, Hong C, Uppu DS, He H, Irvine DJ, Hammond PT. Synthetic Lift-off Polymer beneath Layer-by-Layer Films for Surface- Mediated Drug Delivery. ACS Macro Lett. 2017 Nov 21;6(11):1320-1324. doi: 10.1021/acsmacrolett.7b00584. Epub 2017 Nov 9. PMID: 35650790.

Fan Y, Kuai R, Xu Y, Ochyl LJ, Irvine DJ, Moon JJ. Immunogenic Cell Death Amplified by Co-localized Adjuvant Delivery for Cancer Immunotherapy. Nano Lett. 2017 Dec 13;17(12):7387-7393. doi: 10.1021/acs.nanolett.7b03218. Epub 2017 Nov 22. PMID: 29144754; PMCID: PMC5821496.

Appelbe OK, Moynihan KD, Flor A, Rymut N, Irvine DJ, Kron SJ. Radiation- enhanced delivery of systemically administered amphiphilic-CpG oligodeoxynucleotide. J Control Release. 2017 Nov 28;266:248-255. doi: 10.1016/j.jconrel.2017.09.043. Epub 2017 Oct 5. PMID: 28987882; PMCID: PMC5723529.

Janssen E, Kumari S, Tohme M, Ullas S, Barrera V, Tas JM, Castillo-Rama M, Bronson RT, Usmani SM, Irvine DJ, Mempel TR, Geha RS. DOCK8 enforces immunological tolerance by promoting IL-2 signaling and immune synapse formation in Tregs. JCI Insight. 2017 Oct 5;2(19):e94298. doi: 10.1172/jci.insight.94298. PMID: 28978806; PMCID: PMC5841868.

Moynihan KD, Irvine DJ. Roles for Innate Immunity in Combination Immunotherapies. Cancer Res. 2017 Oct 1;77(19):5215-5221. doi: 10.1158/0008-5472.CAN-17-1340. Epub 2017 Sep 19. PMID: 28928130; PMCID: PMC5647817.

Fotoran WL, Santangelo R, de Miranda BNM, Irvine DJ, Wunderlich G. DNA- Loaded Cationic Liposomes Efficiently Function as a Vaccine against Malarial Proteins. Mol Ther Methods Clin Dev. 2017 Aug 23;7:1-10. doi: 10.1016/j.omtm.2017.08.004. PMID: 28879213; PMCID: PMC5581859.

Yang YS, Atukorale PU, D Moynihan K, Bekdemir A, Rakhra K, Tang L, Stellacci F, Irvine DJ. Erratum: High-throughput quantitation of inorganic nanoparticle biodistribution at the single-cell level using mass cytometry. Nat Commun. 2017 Aug 14;8:15343. doi: 10.1038/ncomms15343. Erratum for: Nat Commun. 2017 Jan 17;8:14069. doi: 10.1038/ncomms14069. PMID: 28805202; PMCID: PMC5561543.

Pauthner M, Havenar-Daughton C, Sok D, Nkolola JP, Bastidas R, Boopathy AV, Carnathan DG, Chandrashekar A, Cirelli KM, Cottrell CA, Eroshkin AM, Guenaga J, Kaushik K, Kulp DW, Liu J, McCoy LE, Oom AL, Ozorowski G, Post KW, Sharma SK, Steichen JM, de Taeye SW, Tokatlian T, Torrents de la Peña A, Butera ST, LaBranche CC, Montefiori DC, Silvestri G, Wilson IA, Irvine DJ, Sanders RW, Schief WR, Ward AB, Wyatt RT, Barouch DH, Crotty S, Burton DR. Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches. Immunity. 2017 Jun 20;46(6):1073-1088.e6. doi: 10.1016/j.immuni.2017.05.007. PMID: 28636956; PMCID: PMC5483234.

Milling L, Zhang Y, Irvine DJ. Delivering safer immunotherapies for cancer. Adv Drug Deliv Rev. 2017 May 15;114:79-101. doi: 10.1016/j.addr.2017.05.011. Epub 2017 May 22. PMID: 28545888; PMCID: PMC5647831.

Zheng Y, Tang L, Mabardi L, Kumari S, Irvine DJ. Enhancing Adoptive Cell Therapy of Cancer through Targeted Delivery of Small-Molecule Immunomodulators to Internalizing or Noninternalizing Receptors. ACS Nano. 2017 Mar 28;11(3):3089-3100. doi: 10.1021/acsnano.7b00078. Epub 2017 Mar 1. PMID: 28231431; PMCID: PMC5647839.

Khademhosseini A, Chan WW, Chhowalla M, Glotzer SC, Gogotsi Y, Hafner JH, Hammond PT, Hersam MC, Javey A, Kagan CR, Kotov NA, Lee ST, Li Y, Möhwald H, Mulvaney PA, Nel AE, Parak WJ, Penner RM, Rogach AL, Schaak RE, Stevens MM, Wee AT, Brinker J, Chen X, Chi L, Crommie M, Dekker C, Farokhzad O, Gerber C, Ginger DS, Irvine DJ, Kiessling LL, Kostarelos K, Landes C, Lee T, Leggett GJ, Liang XJ, Liz-Marzán L, Millstone J, Odom TW, Ozcan A, Prato M, Rao CN, Sailor MJ, Weiss E, Weiss PS. Nanoscience and Nanotechnology Cross Borders. ACS Nano. 2017 Feb 28;11(2):1123-1126. doi: 10.1021/acsnano.7b00953. Epub 2017 Feb 15. PMID: 28199099.

Li J, Wang W, He Y, Li Y, Yan EZ, Zhang K, Irvine DJ, Hammond PT. Structurally Programmed Assembly of Translation Initiation Nanoplex for Superior mRNA Delivery. ACS Nano. 2017 Mar 28;11(3):2531-2544. doi: 10.1021/acsnano.6b08447. Epub 2017 Feb 14. PMID: 28157292; PMCID: PMC5629916.

Hanson MC, Irvine DJ. Synthesis of Lymph Node-Targeting Adjuvants. Methods Mol Biol. 2017;1494:145-152. doi: 10.1007/978-1-4939-6445-1_10. PMID: 27718191.

Ngwa W, Boateng F, Kumar R, Irvine DJ, Formenti S, Ngoma T, Herskind C, Veldwijk MR, Hildenbrand GL, Hausmann M, Wenz F, Hesser J. Smart Radiation Therapy Biomaterials. Int J Radiat Oncol Biol Phys. 2017 Mar 1;97(3):624-637. doi: 10.1016/j.ijrobp.2016.10.034. Epub 2016 Nov 1. PMID: 28126309; PMCID: PMC5302132.

Griffiths KL, Ahmed M, Das S, Gopal R, Horne W, Connell TD, Moynihan KD, Kolls JK, Irvine DJ, Artyomov MN, Rangel-Moreno J, Khader SA. Targeting dendritic cells to accelerate T-cell activation overcomes a bottleneck in tuberculosis vaccine efficacy. Nat Commun. 2016 Dec 22;7:13894. doi: 10.1038/ncomms13894. PMID: 28004802; PMCID: PMC5192216.

Jones RB, Mueller S, Kumari S, Vrbanac V, Genel S, Tager AM, Allen TM, Walker BD, Irvine DJ. Antigen recognition-triggered drug delivery mediated by nanocapsule-functionalized cytotoxic T-cells. Biomaterials. 2017 Feb;117:44-53. doi: 10.1016/j.biomaterials.2016.11.048. Epub 2016 Nov 25. PMID: 27936416; PMCID: PMC5204257.

Tzeng A, Kauke MJ, Zhu EF, Moynihan KD, Opel CF, Yang NJ, Mehta N, Kelly RL, Szeto GL, Overwijk WW, Irvine DJ, Wittrup KD. Temporally Programmed CD8α+ DC Activation Enhances Combination Cancer Immunotherapy. Cell Rep. 2016 Dec 6;17(10):2503-2511. doi: 10.1016/j.celrep.2016.11.020. PMID: 27926855; PMCID: PMC5204262.

Moynihan KD, Opel CF, Szeto GL, Tzeng A, Zhu EF, Engreitz JM, Williams RT, Rakhra K, Zhang MH, Rothschilds AM, Kumari S, Kelly RL, Kwan BH, Abraham W, Hu K, Mehta NK, Kauke MJ, Suh H, Cochran JR, Lauffenburger DA, Wittrup KD, Irvine DJ. Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses. Nat Med. 2016 Dec;22(12):1402-1410. doi: 10.1038/nm.4200. Epub 2016 Oct 24. PMID: 27775706; PMCID: PMC5209798.

Tam HH, Melo MB, Kang M, Pelet JM, Ruda VM, Foley MH, Hu JK, Kumari S, Crampton J, Baldeon AD, Sanders RW, Moore JP, Crotty S, Langer R, Anderson DG, Chakraborty AK, Irvine DJ. Sustained antigen availability during germinal center initiation enhances antibody responses to vaccination. Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):E6639-E6648. doi: 10.1073/pnas.1606050113. Epub 2016 Oct 4. PMID: 27702895; PMCID: PMC5086995.

Steichen JM, Kulp DW, Tokatlian T, Escolano A, Dosenovic P, Stanfield RL, McCoy LE, Ozorowski G, Hu X, Kalyuzhniy O, Briney B, Schiffner T, Garces F, Freund NT, Gitlin AD, Menis S, Georgeson E, Kubitz M, Adachi Y, Jones M, Mutafyan AA, Yun DS, Mayer CT, Ward AB, Burton DR, Wilson IA, Irvine DJ, Nussenzweig MC, Schief WR. HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies. Immunity. 2016 Sep 20;45(3):483-496. doi: 10.1016/j.immuni.2016.08.016. Epub 2016 Sep 8. PMID: 27617678; PMCID: PMC5040827.

Janssen E, Tohme M, Hedayat M, Leick M, Kumari S, Ramesh N, Massaad MJ, Ullas S, Azcutia V, Goodnow CC, Randall KL, Qiao Q, Wu H, Al-Herz W, Cox D, Hartwig J, Irvine DJ, Luscinskas FW, Geha RS. A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeleton. J Clin Invest. 2016 Oct 3;126(10):3837-3851. doi: 10.1172/JCI85774. Epub 2016 Sep 6. PMID: 27599296; PMCID: PMC5096816.

Donius LR, Cheng Y, Choi J, Sun ZY, Hanson M, Zhang M, Gierahn TM, Marquez S, Uduman M, Kleinstein SH, Irvine D, Love JC, Reinherz EL, Kim M. Generation of Long-Lived Bone Marrow Plasma Cells Secreting Antibodies Specific for the HIV-1 gp41 Membrane-Proximal External Region in the Absence of Polyreactivity. J Virol. 2016 Sep 12;90(19):8875-90. doi: 10.1128/JVI.01089-16. PMID: 27466419; PMCID: PMC5021391.

Jones RB, Mueller S, O’Connor R, Rimpel K, Sloan DD, Karel D, Wong HC, Jeng EK, Thomas AS, Whitney JB, Lim SY, Kovacs C, Benko E, Karandish S, Huang SH, Buzon MJ, Lichterfeld M, Irrinki A, Murry JP, Tsai A, Yu H, Geleziunas R, Trocha A, Ostrowski MA, Irvine DJ, Walker BD. A Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4+ T-Cells to Recognition by Cytotoxic T-Lymphocytes. PLoS Pathog. 2016 Apr 15;12(4):e1005545. doi: 10.1371/journal.ppat.1005545. PMID: 27082643; PMCID: PMC4833318.

Moyer TJ, Zmolek AC, Irvine DJ. Beyond antigens and adjuvants: formulating future vaccines. J Clin Invest. 2016 Mar 1;126(3):799-808. doi: 10.1172/JCI81083. Epub 2016 Mar 1. PMID: 26928033; PMCID: PMC4767337.

Irvine DJ. A Receptor for All Occasions. Cell. 2016 Feb 11;164(4):599-600. doi: 10.1016/j.cell.2016.01.030. PMID: 26871625.

Kimmerling RJ, Lee Szeto G, Li JW, Genshaft AS, Kazer SW, Payer KR, de Riba Borrajo J, Blainey PC, Irvine DJ, Shalek AK, Manalis SR. A microfluidic platform enabling single-cell RNA-seq of multigenerational lineages. Nat Commun. 2016 Jan 6;7:10220. doi: 10.1038/ncomms10220. PMID: 26732280; PMCID: PMC4729820.

Dane EL, Irvine DJ. Big thinking for adjuvants. Nat Biotechnol. 2015 Nov;33(11):1146-8. doi: 10.1038/nbt.3398. PMID: 26544144.

Arnold KB, Szeto GL, Alter G, Irvine DJ, Lauffenburger DA. CD4+ T cell- dependent and CD4+ T cell-independent cytokine-chemokine network changes in the immune responses of HIV-infected individuals. Sci Signal. 2015 Oct 20;8(399):ra104. doi: 10.1126/scisignal.aab0808. PMID: 26486173; PMCID: PMC4634873.

Hotaling NA, Tang L, Irvine DJ, Babensee JE. Biomaterial Strategies for Immunomodulation. Annu Rev Biomed Eng. 2015;17:317-49. doi: 10.1146/annurev- bioeng-071813-104814. Epub 2015 Sep 29. PMID: 26421896; PMCID: PMC4798784.

Irvine D, Ploegh H. Editorial overview: Special section: Immunological engineering. Curr Opin Immunol. 2015 Aug;35:ix-xi. doi: 10.1016/j.coi.2015.07.010. Epub 2015 Aug 11. PMID: 26275317.

Mehta NK, Moynihan KD, Irvine DJ. Engineering New Approaches to Cancer Vaccines. Cancer Immunol Res. 2015 Aug;3(8):836-43. doi: 10.1158/2326-6066.CIR-15-0112. Epub 2015 Jul 8. PMID: 26156157; PMCID: PMC4527881.

Irvine DJ, Hanson MC, Rakhra K, Tokatlian T. Synthetic Nanoparticles for Vaccines and Immunotherapy. Chem Rev. 2015 Oct 14;115(19):11109-46. doi: 10.1021/acs.chemrev.5b00109. Epub 2015 Jul 8. PMID: 26154342; PMCID: PMC4688911.

Atukorale PU, Yang YS, Bekdemir A, Carney RP, Silva PJ, Watson N, Stellacci F, Irvine DJ. Influence of the glycocalyx and plasma membrane composition on amphiphilic gold nanoparticle association with erythrocytes. Nanoscale. 2015 Jul 14;7(26):11420-32. doi: 10.1039/c5nr01355k. PMID: 26077112; PMCID: PMC6309694.

Huang B, Abraham WD, Zheng Y, Bustamante López SC, Luo SS, Irvine DJ. Active targeting of chemotherapy to disseminated tumors using nanoparticle- carrying T cells. Sci Transl Med. 2015 Jun 10;7(291):291ra94. doi: 10.1126/scitranslmed.aaa5447. PMID: 26062846; PMCID: PMC4687972.

Szeto GL, Van Egeren D, Worku H, Sharei A, Alejandro B, Park C, Frew K, Brefo M, Mao S, Heimann M, Langer R, Jensen K, Irvine DJ. Microfluidic squeezing for intracellular antigen loading in polyclonal B-cells as cellular vaccines. Sci Rep. 2015 May 22;5:10276. doi: 10.1038/srep10276. PMID: 25999171; PMCID: PMC4441198.

Hanson MC, Crespo MP, Abraham W, Moynihan KD, Szeto GL, Chen SH, Melo MB, Mueller S, Irvine DJ. Nanoparticulate STING agonists are potent lymph node- targeted vaccine adjuvants. J Clin Invest. 2015 Jun;125(6):2532-46. doi: 10.1172/JCI79915. Epub 2015 May 4. PMID: 25938786; PMCID: PMC4497758.

Zhu EF, Gai SA, Opel CF, Kwan BH, Surana R, Mihm MC, Kauke MJ, Moynihan KD, Angelini A, Williams RT, Stephan MT, Kim JS, Yaffe MB, Irvine DJ, Weiner LM, Dranoff G, Wittrup KD. Synergistic innate and adaptive immune response to combination immunotherapy with anti-tumor antigen antibodies and extended serum half-life IL-2. Cancer Cell. 2015 Apr 13;27(4):489-501. doi: 10.1016/j.ccell.2015.03.004. PMID: 25873172; PMCID: PMC4398916.

Liu H, Irvine DJ. Guiding principles in the design of molecular bioconjugates for vaccine applications. Bioconjug Chem. 2015 May 20;26(5):791-801. doi: 10.1021/acs.bioconjchem.5b00103. Epub 2015 Apr 16. PMID: 25822926; PMCID: PMC4694040.

Kumari S, Depoil D, Martinelli R, Judokusumo E, Carmona G, Gertler FB, Kam LC, Carman CV, Burkhardt JK, Irvine DJ, Dustin ML. Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway. Elife. 2015 Mar 11;4:e04953. doi: 10.7554/eLife.04953. PMID: 25758716; PMCID: PMC4355629.

Wang S, Mata-Fink J, Kriegsman B, Hanson M, Irvine DJ, Eisen HN, Burton DR, Wittrup KD, Kardar M, Chakraborty AK. Manipulating the selection forces during affinity maturation to generate cross-reactive HIV antibodies. Cell. 2015 Feb 12;160(4):785-797. doi: 10.1016/j.cell.2015.01.027. Epub 2015 Feb 5. PMID: 25662010; PMCID: PMC4357364.

Hanson MC, Abraham W, Crespo MP, Chen SH, Liu H, Szeto GL, Kim M, Reinherz EL, Irvine DJ. Liposomal vaccines incorporating molecular adjuvants and intrastructural T-cell help promote the immunogenicity of HIV membrane-proximal external region peptides. Vaccine. 2015 Feb 11;33(7):861-8. doi: 10.1016/j.vaccine.2014.12.045. Epub 2015 Jan 2. PMID: 25559188; PMCID: PMC4312707.

Yang YS, Carney RP, Stellacci F, Irvine DJ. Enhancing radiotherapy by lipid nanocapsule-mediated delivery of amphiphilic gold nanoparticles to intracellular membranes. ACS Nano. 2014 Sep 23;8(9):8992-9002. doi: 10.1021/nn502146r. Epub 2014 Aug 20. PMID: 25123510; PMCID: PMC4194056.

Jones RB, O’Connor R, Mueller S, Foley M, Szeto GL, Karel D, Lichterfeld M, Kovacs C, Ostrowski MA, Trocha A, Irvine DJ, Walker BD. Histone deacetylase inhibitors impair the elimination of HIV-infected cells by cytotoxic T-lymphocytes. PLoS Pathog. 2014 Aug 14;10(8):e1004287. doi: 10.1371/journal.ppat.1004287. PMID: 25122219; PMCID: PMC4133386.

Pejawar-Gaddy S, Kovacs JM, Barouch DH, Chen B, Irvine DJ. Design of lipid nanocapsule delivery vehicles for multivalent display of recombinant Env trimers in HIV vaccination. Bioconjug Chem. 2014 Aug 20;25(8):1470-8. doi: 10.1021/bc5002246. Epub 2014 Jul 14. PMID: 25020048; PMCID: PMC4140538.

Hanson MC, Bershteyn A, Crespo MP, Irvine DJ. Antigen delivery by lipid- enveloped PLGA microparticle vaccines mediated by in situ vesicle shedding. Biomacromolecules. 2014 Jul 14;15(7):2475-81. doi: 10.1021/bm500337r. Epub 2014 Jun 16. PMID: 24894061; PMCID: PMC4115588.

Foley MH, Forcier T, McAndrew E, Gonzalez M, Chen H, Juelg B, Walker BD, Irvine DJ. High avidity CD8+ T cells efficiently eliminate motile HIV-infected targets and execute a locally focused program of anti-viral function. PLoS One. 2014 Feb 13;9(2):e87873. doi: 10.1371/journal.pone.0087873. PMID: 24551068; PMCID: PMC3923750.

Liu H, Moynihan KD, Zheng Y, Szeto GL, Li AV, Huang B, Van Egeren DS, Park C, Irvine DJ. Structure-based programming of lymph-node targeting in molecular vaccines. Nature. 2014 Mar 27;507(7493):519-22. doi: 10.1038/nature12978. Epub 2014 Feb 16. PMID: 24531764; PMCID: PMC4069155.

Drake A, Joshi NS, Szeto GL, Zhu E, Eisen HN, Irvine DJ. Koch Institute Symposium on Cancer Immunology and Immunotherapy. Cancer Immunol Res. 2013 Oct;1:217-222. doi: 10.1158/2326-6066.CIR-13-0116. PMID: 24466562; PMCID: PMC3897860.

DeMuth PC, Li AV, Abbink P, Liu J, Li H, Stanley KA, Smith KM, Lavine CL, Seaman MS, Kramer JA, Miller AD, Abraham W, Suh H, Elkhader J, Hammond PT, Barouch DH, Irvine DJ. Vaccine delivery with microneedle skin patches in nonhuman primates. Nat Biotechnol. 2013 Dec;31(12):1082-5. doi: 10.1038/nbt.2759. PMID: 24316643; PMCID: PMC4011140.

Irvine DJ, Swartz MA, Szeto GL. Engineering synthetic vaccines using cues from natural immunity. Nat Mater. 2013 Nov;12(11):978-90. doi: 10.1038/nmat3775. PMID: 24150416; PMCID: PMC3928825.

Li AV, Moon JJ, Abraham W, Suh H, Elkhader J, Seidman MA, Yen M, Im EJ, Foley MH, Barouch DH, Irvine DJ. Generation of effector memory T cell-based mucosal and systemic immunity with pulmonary nanoparticle vaccination. Sci Transl Med. 2013 Sep 25;5(204):204ra130. doi: 10.1126/scitranslmed.3006516. PMID: 24068737; PMCID: PMC3934930.

Kim M, Song L, Moon J, Sun ZY, Bershteyn A, Hanson M, Cain D, Goka S, Kelsoe G, Wagner G, Irvine D, Reinherz EL. Immunogenicity of membrane-bound HIV-1 gp41 membrane-proximal external region (MPER) segments is dominated by residue accessibility and modulated by stereochemistry. J Biol Chem. 2013 Nov 1;288(44):31888-901. doi: 10.1074/jbc.M113.494609. Epub 2013 Sep 18. PMID: 24047898; PMCID: PMC3814781.

Van Lehn RC, Atukorale PU, Carney RP, Yang YS, Stellacci F, Irvine DJ, Alexander-Katz A. Effect of particle diameter and surface composition on the spontaneous fusion of monolayer-protected gold nanoparticles with lipid bilayers. Nano Lett. 2013 Sep 11;13(9):4060-7. doi: 10.1021/nl401365n. Epub 2013 Aug 20. PMID: 23915118; PMCID: PMC4177149.

DeMuth PC, Min Y, Irvine DJ, Hammond PT. Implantable silk composite microneedles for programmable vaccine release kinetics and enhanced immunogenicity in transcutaneous immunization. Adv Healthc Mater. 2014 Jan;3(1):47-58. doi: 10.1002/adhm.201300139. Epub 2013 Jul 12. PMID: 23847143; PMCID: PMC3950936.

Zheng Y, Stephan MT, Gai SA, Abraham W, Shearer A, Irvine DJ. In vivo targeting of adoptively transferred T-cells with antibody- and cytokine- conjugated liposomes. J Control Release. 2013 Dec 10;172(2):426-35. doi: 10.1016/j.jconrel.2013.05.037. Epub 2013 Jun 11. PMID: 23770010; PMCID: PMC4046900.

Demuth PC, Garcia-Beltran WF, Ai-Ling ML, Hammond PT, Irvine DJ. Composite dissolving microneedles for coordinated control of antigen and adjuvant delivery kinetics in transcutaneous vaccination. Adv Funct Mater. 2013 Jan 14;23(2):161-172. doi: 10.1002/adfm.201201512. PMID: 23503923; PMCID: PMC3595545.

Ackerman ME, Dugast AS, McAndrew EG, Tsoukas S, Licht AF, Irvine DJ, Alter G. Enhanced phagocytic activity of HIV-specific antibodies correlates with natural production of immunoglobulins with skewed affinity for FcγR2a and FcγR2b. J Virol. 2013 May;87(10):5468-76. doi: 10.1128/JVI.03403-12. Epub 2013 Mar 6. PMID: 23468489; PMCID: PMC3648186.

Su X, Yang N, Wittrup KD, Irvine DJ. Synergistic antitumor activity from two-stage delivery of targeted toxins and endosome-disrupting nanoparticles. Biomacromolecules. 2013 Apr 8;14(4):1093-102. doi: 10.1021/bm3019906. Epub 2013 Mar 11. PMID: 23444913; PMCID: PMC3646422.

Kwong B, Gai SA, Elkhader J, Wittrup KD, Irvine DJ. Localized immunotherapy via liposome-anchored Anti-CD137 + IL-2 prevents lethal toxicity and elicits local and systemic antitumor immunity. Cancer Res. 2013 Mar 1;73(5):1547-58. doi: 10.1158/0008-5472.CAN-12-3343. Epub 2013 Feb 22. PMID: 23436794; PMCID: PMC3594475.

Wang Y, Irvine DJ. Convolution of chemoattractant secretion rate, source density, and receptor desensitization direct diverse migration patterns in leukocytes. Integr Biol (Camb). 2013 Mar;5(3):481-94. doi: 10.1039/c3ib20249f. PMID: 23392181; PMCID: PMC3597436.

DeMuth PC, Min Y, Huang B, Kramer JA, Miller AD, Barouch DH, Hammond PT, Irvine DJ. Polymer multilayer tattooing for enhanced DNA vaccination. Nat Mater. 2013 Apr;12(4):367-76. doi: 10.1038/nmat3550. Epub 2013 Jan 27. PMID: 23353628; PMCID: PMC3965298.

Yamanaka YJ, Szeto GL, Gierahn TM, Forcier TL, Benedict KF, Brefo MS, Lauffenburger DA, Irvine DJ, Love JC. Cellular barcodes for efficiently profiling single-cell secretory responses by microengraving. Anal Chem. 2012 Dec 18;84(24):10531-6. doi: 10.1021/ac302264q. Epub 2012 Dec 3. PMID: 23205933; PMCID: PMC3691955.

Mata-Fink J, Kriegsman B, Yu HX, Zhu H, Hanson MC, Irvine DJ, Wittrup KD. Rapid conformational epitope mapping of anti-gp120 antibodies with a designed mutant panel displayed on yeast. J Mol Biol. 2013 Jan 23;425(2):444-56. doi: 10.1016/j.jmb.2012.11.010. Epub 2012 Nov 15. PMID: 23159556; PMCID: PMC3785227.

DeMuth PC, Moon JJ, Suh H, Hammond PT, Irvine DJ. Releasable layer-by-layer assembly of stabilized lipid nanocapsules on microneedles for enhanced transcutaneous vaccine delivery. ACS Nano. 2012 Sep 25;6(9):8041-51. doi: 10.1021/nn302639r. Epub 2012 Aug 30. PMID: 22920601; PMCID: PMC3475723.

Moon JJ, Huang B, Irvine DJ. Engineering nano- and microparticles to tune immunity. Adv Mater. 2012 Jul 24;24(28):3724-46. doi: 10.1002/adma.201200446. Epub 2012 May 29. PMID: 22641380; PMCID: PMC3786137.

Stephan MT, Stephan SB, Bak P, Chen J, Irvine DJ. Synapse-directed delivery of immunomodulators using T-cell-conjugated nanoparticles. Biomaterials. 2012 Aug;33(23):5776-87. doi: 10.1016/j.biomaterials.2012.04.029. Epub 2012 May 15. PMID: 22594972; PMCID: PMC3395588.

Moon JJ, Suh H, Polhemus ME, Ockenhouse CF, Yadava A, Irvine DJ. Antigen- displaying lipid-enveloped PLGA nanoparticles as delivery agents for a Plasmodium vivax malaria vaccine. PLoS One. 2012;7(2):e31472. doi: 10.1371/journal.pone.0031472. Epub 2012 Feb 6. PMID: 22328935; PMCID: PMC3273465.

Moon JJ, Suh H, Li AV, Ockenhouse CF, Yadava A, Irvine DJ. Enhancing humoral responses to a malaria antigen with nanoparticle vaccines that expand Tfh cells and promote germinal center induction. Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1080-5. doi: 10.1073/pnas.1112648109. Epub 2012 Jan 12. PMID: 22247289; PMCID: PMC3268296.

Metallo CM, Gameiro PA, Bell EL, Mattaini KR, Yang J, Hiller K, Jewell CM, Johnson ZR, Irvine DJ, Guarente L, Kelleher JK, Vander Heiden MG, Iliopoulos O, Stephanopoulos G. Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia. Nature. 2011 Nov 20;481(7381):380-4. doi: 10.1038/nature10602. PMID: 22101433; PMCID: PMC3710581.

Jewell CM, Jung JM, Atukorale PU, Carney RP, Stellacci F, Irvine DJ. Oligonucleotide delivery by cell-penetrating “striped” nanoparticles. Angew Chem Int Ed Engl. 2011 Dec 16;50(51):12312-12315. doi: 10.1002/anie.201104514. Epub 2011 Oct 26. PMID: 22028047; PMCID: PMC3786135.

Jewell CM, López SC, Irvine DJ. In situ engineering of the lymph node microenvironment via intranodal injection of adjuvant-releasing polymer particles. Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):15745-50. doi: 10.1073/pnas.1105200108. Epub 2011 Sep 6. PMID: 21896725; PMCID: PMC3179077.

Stephan MT, Irvine DJ. Enhancing Cell therapies from the Outside In: Cell Surface Engineering Using Synthetic Nanomaterials. Nano Today. 2011 Jun 1;6(3):309-325. doi: 10.1016/j.nantod.2011.04.001. PMID: 21826117; PMCID: PMC3148657.

Martínez-Martín N, Fernández-Arenas E, Cemerski S, Delgado P, Turner M, Heuser J, Irvine DJ, Huang B, Bustelo XR, Shaw A, Alarcón B. T cell receptor internalization from the immunological synapse is mediated by TC21 and RhoG GTPase-dependent phagocytosis. Immunity. 2011 Aug 26;35(2):208-22. doi: 10.1016/j.immuni.2011.06.003. Epub 2011 Aug 4. PMID: 21820331; PMCID: PMC4033310.

Bershteyn A, Hanson MC, Crespo MP, Moon JJ, Li AV, Suh H, Irvine DJ. Robust IgG responses to nanograms of antigen using a biomimetic lipid-coated particle vaccine. J Control Release. 2012 Feb 10;157(3):354-65. doi: 10.1016/j.jconrel.2011.07.029. Epub 2011 Jul 24. PMID: 21820024; PMCID: PMC3811132.

Yoo JW, Irvine DJ, Discher DE, Mitragotri S. Bio-inspired, bioengineered and biomimetic drug delivery carriers. Nat Rev Drug Discov. 2011 Jul 1;10(7):521-35. doi: 10.1038/nrd3499. PMID: 21720407.